Work

Aortitis in VEXAS Syndrome

Year: 2025

Type: article

Abstract: A 74-year-old man was referred for fever of unknown origin lasting four weeks.The patient had no cranial symptoms, including auricular chondritis.Large-vessel giant cell arteritis was suspected because the aorta showed uptake on fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) (Picture 1, 2, arrows).The fever abated with corticosteroid therapy, but recurred after dosage reduction.Macrocytic anemia and vacuoles in the bone marrow erythroblasts led to the suspicion of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syn-

Source: Internal Medicine

DOI: 10.2169/internalmedicine.5069-24

Authors: Junichi Tsuchiya, Takahiro Nunokawa, Shino Sogabe, Naofumi Chinen

Institutions: Tokyo Metropolitan Tama-Nambu Chiiki Hospital, Tokyo Metropolitan Tama-Nambu Hospital

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Kanazawa University