Work

Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions

Year: 2025

Type: article

Abstract: Decision-making in mammals fundamentally relies on integrating multiple sensory inputs, with conflicting information resolved flexibly based on a dominant sensory modality. However, the neural mechanisms underlying state-dependent changes in sensory dominance remain poorly understood. Our study demonstrates that locomotion in mice shifts auditory-dominant decisions toward visual dominance during audiovisual conflicts. Using circuit-specific calcium imaging and optogenetic manipulations, we found that weakened visual representation in the posterior parietal cortex (PPC) leads to auditory-dominant decisions in stationary mice. Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC PPC ). This shift is mediated by secondary motor cortical neurons projecting to the auditory cortex (M2 AC ), which specifically inhibit AC PPC neurons without affecting auditory cortical projections to the striatum (AC STR ). Our findings reveal the neural circuit mechanisms underlying auditory gating to the association cortex depending on locomotion states, providing insights into the state-dependent changes in sensory dominance during multisensory decision-making.

Source: Nature Communications

DOI: 10.1038/s41467-025-57347-y

Authors: Ilsong Choi, Seung-Hee Lee

Institutions: Institute for Basic Science, Korea Advanced Institute of Science and Technology

Language: English

Topic: Multisensory perception and integration

Subfield: Experimental and Cognitive Psychology

Field: Psychology

Domain: Social Sciences

Open Access status: gold

Estimated APC paid: $6,990

Funders: National Research Foundation, National Research Foundation of Korea, Institute for Basic Science