Kratom Cardiotoxicity
Year: 2025
Type: article
Study design: Case Report
Abstract: Kratom is derived from Mitragyna speciosa and contains active alkaloids that bind opioid, alpha-2 adrenergic, and 5-HT2A receptors. In vitro studies show kratom can inhibit myocardial potassium channels. We present a patient who developed a reversible Brugada pattern and QT prolongation after self-treating his attention-deficit/hyperactivity disorder with kratom.
Source: JACC Case Reports
Authors: Andrew H.F. Miller, Alex J. Krotulski, Sara E. Walton, Anna R. Dulaney, Aaron P. Frolichstein, Haley L. Dusek, Christine Murphy
Institutions: Carolinas Medical Center, Fredric Rieders Family Foundation
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $850
OpenAlex ID: W4408216558