Work

Spatial confinement and life under pressure from physiology to pathology

Year: 2025

Type: article

Abstract: Tree roots sprouting into the ground or tumors proliferating within an organ are a few examples of proliferation under spatial confinement, which leads to growth-induced pressure. This compressive mechanical stress can impact a plethora of processes in all organisms. In this review, I will discuss the physiological and pathological consequences of spatial confinement in plants, microbes and animal cells, and will discuss in more depth the case of solid tumors.

Source: npj Biological Physics and Mechanics.

DOI: 10.1038/s44341-025-00013-7

Author: Morgan Delarue

Institutions: Centre National de la Recherche Scientifique, Laboratoire d'Analyse et d'Architecture des Systèmes, Université de Toulouse

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $2,490

Funder: European Research Council