Work

Reduced Prostaglandin D2 Production by Airway Fibroblasts in Nonsteroidal Anti-inflammatory Drug- Exacerbated Airway Disease

Year: 2025

Type: article

Abstract: Nasal mucosa (NM) specimens were obtained from seven subjects (one woman, 34±2.9 yr) who had septal deviations or turbinate hypertrophy and underwent corrective surgery (control-NM).Nasal polyp (NP) specimens were collected from seven patients with AERD (four women, 48.3±2.6 yr) and from seven non-AERD patients (three women, 44.3±16.6 yr) who were treated with endoscopic surgery.The diagnosis of aspirin intolerance was confirmed by utilising an oral or lysine-aspirin nasal challenge.None of the subjects received oral or intranasal corticosteroids for at least one week before the operation or had upper airway infections in the two weeks before the operation.Control and non-AERD subjects had taken aspirin or NSAIDs without adverse reactions (asthma, rhinitis, urticaria, angioedema, or anaphylaxis).The laboratory staff involved in the ELISA study were unaware of which group the samples came from.

Source: Journal of Investigational Allergology and Clinical Immunology

DOI: 10.18176/jiaci.1062

Authors: J Roca-Ferrer, L Machado-Carvalho, C Picado

Institutions: Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, University of Trás-os-Montes and Alto Douro, Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408219544