Work

Transient angiotensin-converting enzyme inhibition confers sex-specific protection against angiotensin II-induced cardiac remodeling

Year: 2025

Type: article

Abstract: Here, we determine, for the first time that female spontaneously hypertensive rats are responsive to transient angiotensin-converting enzyme inhibitor (ACEi) treatment. Prior work showed that transient ACEi treatment induced persistent protection against a future stimulus in males. Here, Ang II-induced cardiac fibrosis was attenuated by transient ACEi treatment in both sexes. Notably, the underlying mechanism of action is sex-dependent. Specifically, changes in collagen deposition in male but not female hearts correlate with collagen gene expression.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00753.2024

Authors: Alexandra M. Garvin, Dana B. Floyd, Alexis C. Bailey, Merry L. Lindsey, Chad C. Carroll, Taben M. Hale