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69P Development and characterization of a terbium-161 radioconjugate for selective targeting of carbonic anhydrase IX in hypoxic colorectal tumors

Year: 2025

Type: article

Abstract: Carbonic anhydrase IX (CAIX) is a transmembrane metalloenzyme that is frequently upregulated in solid hypoxic tumors to acidify their microenvironment, enhancing metastasis and invasiveness. Its overexpression on malignant cells and limited expression in normal tissues make CAIX an appealing target for theranostic applications.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2025.104228

Authors: C. Segers, K. Vermeulen, A. Coolkens, M. Crabbé, M. Ooms, T. Opsomer

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910

OpenAlex ID: W4408220214

FWCI:

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