Work

113P Relevance of RB1 and TP53 alteration detecting via liquid biopsy for neuroendocrine phenotype assessment and shifting

Year: 2025

Type: article

Abstract: Neuroendocrine neoplasms are a heterogeneous class of rare tumours accounting for ∼2% of all malignancies. Despite they primarily arise from neuroendocrine cells, some of the more common adenocarcinomas can transform into NECs (Neuroendocrine cancers) under the pressure of anticancer treatments. Identification of transformed NEC (tNEC) is challenged by the poor feasibility of tissue biopsies. Genome alterations such as RB1loss and TP53 mutation are typically co-associated within NECs and testing via liquid biopsy could represent a valid approach to detect tNECs years after the original histology.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2025.104274