Multiplexed fiber meta-tip–based circular polarimetry for label-free pathological analysis of ischemic stroke
Year: 2025
Type: article
Abstract: Significance: We present an optical technology for a full-process label-free method for brain slice screening. This proposed multiplexed circular polarimetric method has the advantages of simple operation and high accuracy which may provide easily accessible evidence for the future diagnosis of related diseases. Aim: One of its missions is to provide a quantifiable, reproducible analysis methodology that can replace or supplement traditional qualitative, subjective pathological analysis. Approach: A label-free, sensitive, and rapid circular polarimetric method based on a multiplexed optical fiber meta-tip is proposed for the digital pathology of ischemic stroke. Polarization information of forward-scattered light is used to identify pathological variations of axon distribution in ischemic stroke tissues. The newly designed optical fiber meta-tip with four channels offers miniature illumination in the multiplexed circular polarimetry method. Results: Our automated approach achieves more than 90% area under the curve in classifying ischemic stroke brain tissue in around 1 min. Conclusions: The high-sensitivity and label-free circular polarimetric method based on the multiplexed optical fiber meta-tip renders its potential for rapid digital pathology of various diseases. It will empower the application of digital pathology in future disease diagnosis by quantitatively introducing a new reliable data modality without altering currently established processes.
Source: Neurophotonics
Institutions: Beihang University, Peking University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,675
Award: G7341008783
OpenAlex ID: W4408220974