Work

32P Investigating the mechanistic pathways of a novel HDAC inhibitor in neuroblastoma

Year: 2025

Type: article

Abstract: Histone deacetylases (HDACs) play a major role in tumor progression and the development of multidrug resistance in neuroblastoma. Consequently, HDAC inhibitors (HDACis) have been introduced to induce cell cycle arrest, promote apoptosis and enhance cancer cell sensitivity to apoptotic pathways. These inhibitors increase histone acetylation, thereby activating tumor suppressor genes. Additionally, HDACis also affect non-histone proteins, such as Bax, p53, Bcl-2, and p21, facilitating apoptosis and helping to overcome resistance mechanisms in neuroblastoma.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2025.104190

Authors: P. Pai, M.G. Shetty, Y.R. S R, K. Satyamoorthy, B.K. Sundara

Institutions: Manipal Academy of Higher Education, Shri Dharmasthala Manjunatheshwara University

Language: English

Topic: Histone Deacetylase Inhibitors Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910