Work

ChREBP mediates metabolic remodeling in FBP1-deficient liver

Year: 2025

Type: article

Abstract: FBP1 deficiency in adulthood causes progressive hepatic steatosis due to the overactivation of ChREBP pathway, which enhances lipid synthesis and inhibits fat oxidation. ChREBP-mediated metabolic remodeling protects against liver injury caused by energy deficit and oxidative stress in FBP1-deficient liver.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00875.2024

Authors: Chen-Ma Wang, Qiu-Fang Bai, Ya-Jin Liu, Jie Lin, Chun-Chun Wei, Xian-Hua Ma, Jia-Mu Zhao, Meng Zhu, Yu-Xia Chen, Ya-Nan Shi, Jian-Hui Shi, Weiping J. Zhang

Institutions: Tianjin Medical University, Second Affiliated Hospital of Zhengzhou University, Second Military Medical University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Natural Science Foundation of China, National Key Research and Development Program of China

Awards: G136865841, G1665739099, G3929125960, G6470155694

OpenAlex ID: W4408221600

FWCI: 2.429

Cites: 37

Cited by: 4

Related to: 10