Contignasterines, Anti-Inflammatory 2-Aminoimidazole Steroids from the Sponge Neopetrosia cf. rava Collected in the Bismarck Sea
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Sponges of the genus Neopetrosia are known for the production of a large diversity of bioactive metabolites. Contignasterines A ( 1 ) and B ( 2 ) were isolated as major metabolites of the sponge Neopetrosia cf. rava collected in the Bismarck Sea along with the known and highly bioactive steroid contignasterol ( 3 ) possessing a similar oxidized aglycone. Contignasterines are characterized by the presence of a 2-aminoimidazole branched on the side-chains of the oxidized steroid, and 1 also contains an unusual phosphate group at C-7. The anti-inflammatory activities of these compounds were investigated and revealed that all three compounds inhibited the production of pro-inflammatory mediators.
Source: Journal of Natural Products
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: École Pratique des Hautes Études, Université de Recherche Paris Sciences et Lettres, Walt Disney Company, L'Oreal USA, United Nations Educational, Scientific and Cultural Organization, Ministerio de Ciencia, Innovación y Universidades, Fondation Tara Océan, Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Universidad de Jaén, Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, Université de Recherche Paris Sciences et Lettres, Xunta de Galicia, Fondation Veolia Environnement, Prince Albert II of Monaco Foundation, Région Bretagne, Université Côte d’Azur, Fonds Français pour l'Environnement Mondial, HORIZON EUROPE Framework Programme, Agencia Estatal de Investigación, Interreg, H2020 Marie Skłodowska-Curie Actions, HORIZON EUROPE Food, Bioeconomy, Natural Resources, Agriculture and Environment, NextGenerationEU
OpenAlex ID: W4408222039