A clinicopathological features and treatment of lacrimal gland tumors at a tertiary eye hospital in Nepal
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: To evaluate the clinico-demographic profile, histopathological findings, and treatment of patients with lacrimal gland tumors. Methods: This was a retrospective study of patients with lacrimal gland tumors diagnosed and managed at the Oculoplastic and Ocular Oncology department of a tertiary eye hospital in Nepal. Twenty-three patients with biopsy-proven lacrimal gland tumors between January 2017 and December 2021 were included. The clinical characteristics, histopathologic diagnosis, and their management were evaluated. Results: A total of 24 eyes of 23 patients were retrospectively reviewed. The mean age of patients was 41.67 ± 13.7 (17-60 years). Females 13 (54.2%) were more commonly affected. Most patients presented with a palpable mass in the periorbital region 10 (41.6%) followed by protrusion of the eyeball six (25%). The mean duration of symptoms was 10.8 months. The diagnosis was made clinically and radiologically and confirmed by histopathology. Surgical excision of the tumor was done in 18 (75%), followed by incision biopsy three (12.5%) and exenteration two (8.3%). Histopathology showed pleomorphic adenoma 11 (45.8%) as the most common lacrimal gland tumor, followed by adenoid cystic carcinoma seven (29.1%), adenocarcinoma three (12.8%), lymphoma two (8.3%) and carcinoma ex pleomorphic adenoma one (4.2%). Malignant tumors were treated by wide surgical excision followed by adjuvant treatment after consultation with an oncologist. Conclusion: The most common benign lacrimal gland tumor was pleomorphic adenoma and malignant was adenoid cystic carcinoma. The histopathological diagnosis was important to plan for the management of lacrimal gland tumors which have a significant role in the survival of the patient.
Source: Annals of Medicine and Surgery
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,850
OpenAlex ID: W4408223484