Discussing the Interplay of Social Determinants of Health, Aging, and Alzheimer’s Biomarkers in U.S. Latinos
Year: 2025
Type: article
Abstract: This perspective examines the impact of Social Determinants of Health (SDoH) on the biological age-related decline and Alzheimer's Disease and Related Dementias (ADRD) biomarker trajectories in U.S. Latino populations, emphasizing the need for comprehensive multilevel research frameworks tailored to the community. We discuss the prevailing SDoH among U.S. Latino communities, including economic, educational, and healthcare access inequities that heighten health risks. Subsequently, we examine the pronounced differences in ADRD prevalence and biomarker trajectories among Latinos, suggesting that the interplay between SDoH and biological markers contributes to ADRD risk and progression. Our perspective reflects on the existing research landscape, noting a substantial gap in studies extending beyond identifying and understanding disparities in ADRD, to research incorporating biomarkers and developing actionable interventions to address broader SDoH. This shift is essential for creating a more holistic approach to ADRD research and devising truly effective strategies to mitigate ADRD disparities and improve brain health for older U.S. Latinos.
Authors: Jairo E Martinez, Jaime Perales-Puchalt, Miriam J Rodriguez, Monica Rosselli, Christian Salazar, David X Marquez, Melissa Lamar, Clara Vila-Castelar, Katya Rascovsky, Sid O’Bryant, Raul Vintimilla, Mirella Díaz-Santos, Idaly Velez Uribe, Yakeel T Quiroz, Jorge J Llibre-Guerra, Jairo E Martinez, Jaime Perales-Puchalt, Miriam J Rodriguez, Monica Rosselli, Christian Salazar, David X Marquez, Melissa Lamar, Clara Vila-Castelar, Katya Rascovsky, Sid O’Bryant, Raul Vintimilla, Mirella Díaz-Santos, Idaly Velez Uribe, Yakeel T Quiroz, Jorge J Llibre-Guerra
Institutions: Boston University, Harvard University, Massachusetts General Hospital, University of Kansas Medical Center, Indiana University Bloomington, Indiana University, Florida Atlantic University, University of California, Irvine, Rush University Medical Center, University of Illinois Chicago, University of Pennsylvania, University of North Texas, University of North Texas Health Science Center, University of California, Los Angeles, Mount Sinai Medical Center, Washington University in St. Louis
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1051870491, G1069732457, G1185545789, G1857158372, G192411205, G3024779057, G4080699862, Leveraging the Electronic Health Record and Integrating Social and Biological Data to Expand Dementia Research in Understudied Populations in Los Angeles County, G5291542082, G802800449, G8131448647, G8313191639, G8422612049, Culturally relevant contributors to cognitive and MRI changes in older Latinos, University of Kansas Alzheimer's Disease Research Center (KU ADRC), G934091397
OpenAlex ID: W4408225843