Work

Single-crystal structure of the spicy capsaicin

Year: 2025

Type: article

Abstract: ), or trans-8-methyl-N-vanillylnon-6-enamide, the natural product responsible for the spiciness of chilli peppers, was determined using low-temperature single-crystal X-ray diffraction. The reported crystal structure is in good agreement with previous determinations based on powder X-ray diffraction data. The localization and free refinement of all H atoms revealed that each capsaicin molecule is hydrogen bonded to four other molecules, with the O-H and N-H groups acting as hydrogen-bond donors, and the C=O group serving as a bifurcated hydrogen-bond acceptor.

Source: Acta Crystallographica Section C Structural Chemistry

DOI: 10.1107/s2053229625001706

Author: Matic Lozinšek

Institutions: Jožef Stefan Institute, Jožef Stefan International Postgraduate School

Language: English

Topic: Crystal structures of chemical compounds

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,950

Funder: European Commission