Prognostic value of lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) in patients with locally advanced triple-negative breast cancer: An oncological-high flow center experience
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: This study aims to investigate the prognostic value of lymph node ratio (LNR) and log odds of positive lymph nodes (LODDS) in patients with locally advanced, nonmetastatic (Stage II–III) triple-negative breast cancer (TNBC). Methods: In this observational, monocenter, retrospective study, patients who underwent breast surgery for locally advanced TNBC were analyzed. Clinical-pathological features of interest were collected. The log-rank statistics method and the Cox proportional hazard analysis were used to identify prognostic factors. Disease-free survival (DFS) and overall survival (OS) curves were evaluated by the Kaplan–Meier method, using the log-rank test to compare survival between groups. Results: Between 2011 and 2016, 82 patients were included in the study. The median follow-up was 33 months. Cox’s univariate analysis showed that T stage, positive lymph nodes, LODDS, and LNR were statistically significant prognostic factors for DFS (P < 0.05). In the Multivariate Cox analysis, LNR was the only independent prognostic factor for DFS (P < 0.0001). Conclusions: LNR and LODDS can provide additional prognostic value for DFS and OS in locally advanced TNBC. Moreover, LNR had a better prognostic value compared with LODDS. These data should be considered in the overall care strategy of these patients, especially in the decisions on possible adjuvant therapy.
Authors: Ilaria Puccica, Sonia Cappelli, Marco Clementi, Marco Mazzotta, Diletta Corallino, Patrizia Vici, Letizia Perracchio, Isabella Sperduti, Maurizio Costantini, Claudio Botti
Institutions: Instituto Nazionale Tumori Regina Elena, University of L'Aquila, Ospedale Sandro Pertini, St. Eugenio Hospital, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Istituti di Ricovero e Cura a Carattere Scientifico
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4408225903