Work

The vitamin D3 hormone, 1,25(OH)2D3, regulates fibroblast growth factor 23 (FGF23) production in human skin cells

Year: 2025

Type: article

Abstract: This study shows for the first time the expression and secretion of the FGF23 hormone by human skin cells. In addition, we identified the active vitamin D3 hormone, 1,25(OH)2D3, to be a potent regulator of dermal FGF23 expression and protein secretion, partly involving the vitamin D receptor. Furthermore, we provide initial evidence demonstrating that FGF23 upregulates the gene expression of CYP11A1 and CYP27A1 in keratinocytes.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00827.2024

Authors: Franz Ewendt, Zorica Janjetovic, Tae-Kang Kim, Alisa A. Mobley, Anna A. Brożyna, Senthilkumar Ravichandran, Adrian Fabisiak, Pawel Brzeminski, Rafal R. Sicinski, Gabriele I. Stangl, Robert C. Tuckey, Andrzej T. Slominski

Institutions: University of Alabama at Birmingham, UAB Medicine, Nicolaus Copernicus University, University of Warsaw, Martin Luther University Halle-Wittenberg, The University of Western Australia, Birmingham VA Medical Center

Language: English

Topic: Parathyroid Disorders and Treatments

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: U.S. Department of Defense, U.S. Department of Veterans Affairs, Deutsche Forschungsgemeinschaft, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: G1754969554, G2913712177, G3323338009, Bioverfügbarkeit, saisonale Variabilität und Metabolisierung von Photoisomeren des Vitamin D im Menschen, G6433949306, NONCALCEMIC VITAMIN D-HYDROXY DERIVATIVES AS PREVENTIVE AND THERAPEUTIC AGENTS IN UVB-INDUCED MELANOMA, G777201060, G8478614805, G9000036698, G9000186128, G9000317130

OpenAlex ID: W4408231126

FWCI: 2.406

Cites: 86

Cited by: 4

Related to: 10