Work

Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate

Year: 2025

Type: article

Source: Science Immunology

DOI: 10.1126/sciimmunol.ado3032

Authors: Yinghui J. Huang, Shin Foong Ngiow, Amy E. Baxter, Sasikanth Manne, Simone L. Park, Jennifer E. Wu, Omar Khan, Josephine R. Giles, E. John Wherry

Institution: University of Pennsylvania

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Institutes of Health, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Testing the role of BATF as a pioneer transcription factor in effector T cells, G1618383224, G1690409392, Training Program/Rheumatic Diseases, G2583384803, G2789168619, G41353926, G4424250656, Engineering T cells to Provide Durable Control of HIV-1 Replication, Temporal control of differentiation and epigenetics of Exhausted CD8 T cells by Tox, Radiation and checkpoint blockade for cancer immune therapy

OpenAlex ID: W4408236094

FWCI: 14.73

Cites: 66

Cited by: 50

Related to: 10