Multidisciplinary approach to treating complex immune dysregulation disorders: an adaptive model for institutional implementation
Year: 2025
Type: review
Abstract: Patients with immune dysregulation may present with varying combinations of autoimmunity, autoinflammation, immunodeficiency, atopy, lymphoproliferation, and/or malignancy, often with multisystem involvement. Recognizing specific patterns of immune dysregulation, coordinating and interpreting complex diagnostic testing, and choosing initial (often empiric) treatment can be challenging. Centers are increasingly assembling multidisciplinary teams (MDTs) to standardize evaluation and optimize treatment of patients with complex immune dysregulation (immune dysregulation MDTs [immMDTs]). However, published information on the composition and function of immMDTs is sparse, and there is little guidance for those seeking to establish or optimize an immMDT. To inform this review, we assembled a panel of 24 pediatric providers from multiple specialties who actively participate in immMDTs to provide expert opinion. We also conducted a search of the available information on pediatric immMDTs from PubMed. Based on these insights, we summarize the structure and function of active immMDTs across the United States and focus on best practices and context-dependent solutions that may enable institutions with varying goals, patient populations, and resources to establish an immMDT.
Source: Frontiers in Immunology
Authors: Lauren A. Henderson, Roshini S. Abraham, Aisha Ahmed, Lindsey Blount, Scott W. Canna, Natalia S. Chaimowitz, Shanmuganathan Chandrakasan, Bria Coates, James A. Connelly, Megan A. Cooper, Christine N. Duncan, Anthony French, Melissa Hazen, Michelle L. Hermiston, Brian Nolan, Anish Ray, Melissa J. Rose, Lisa Forbes Satter, Grant Schulert, Sara Kristen Sexson Tejtel, Tiphanie Vogel, Kelly Walkovich, Matt S. Zinter, Edward M. Behrens
Institutions: Boston Children's Hospital, Nationwide Children's Hospital, Northwestern University, Lurie Children's Hospital, Children's Hospital of Philadelphia, University of Pennsylvania, Cook Children's Medical Center, Emory University, Children's Healthcare of Atlanta, Vanderbilt University Medical Center, Washington University in St. Louis, Harvard University, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, University of California, San Francisco, UCSF Benioff Children's Hospital, University of North Texas Health Science Center, The Ohio State University, Baylor College of Medicine, Texas Children's Hospital, Cincinnati Children's Hospital Medical Center, University of Cincinnati, University of Michigan, C. S. Mott Children's Hospital
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408238723