Work

Preparation of Macrobicyclic Cryptands for Radiometal Complexation

Year: 2025

Type: article

Abstract: ABSTRACT Macrobicyclic cryptands and especially derivatives with functionalized side arms (picolinate, pyrimidine carboxylate, and bipyridine carboxylate) are able to complex metal ions effectively. In this regard, four new functionalized cryptands were prepared in a convenient two‐step synthesis procedure starting from basic compound 4,10,16,22,27‐pentaoxa‐1,7,13,19‐tetraazabicyclo[11.11.5]nonacosane and fully characterized. Their complexation behavior was tested via 1H NMR titration with Ba2+, Sc3+, La3+, Lu3+, In3+, and Pb2+ pointing out log K values between 1.4 and 4.0. Radiolabeling with selected cations of radiopharmaceutical relevance (131Ba, 225Ac, and 133La) was performed.

Source: Journal of Labelled Compounds and Radiopharmaceuticals

DOI: 10.1002/jlcr.4136

Authors: Laura Höffmann, Magdalena Blei, Falco Reissig, Klaus Kopka, Constantin Mamat

Institutions: Helmholtz-Zentrum Dresden-Rossendorf, Technische Universität Dresden, University Hospital Carl Gustav Carus, Nationales Centrum für Tumorerkrankungen Dresden, German Cancer Consortium (DKTK) Dresden

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $3,800

OpenAlex ID: W4408245029

FWCI: 0.528

Cites: 30

Cited by: 1

Related to: 10