Pocket guide: biologics in upper and lower airways in adults
Year: 2025
Type: article
Abstract: The introduction of biologics for the treatment of severe upper and lower (type 2) airway inflammation has been a game changer in the management of these diseases. Biologics are injectable medications targeting different molecules relevant in (type 2) inflammation in patients with severe (type 2) airway diseases, like asthma, eosinophilic chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis (CRS) and those who remain uncontrolled despite regular treatment. After the phase 3 trials, showing significant impact on symptoms, quality of life and interventions like surgery (for the upper airways) and exacerbations needing hospitalisation (for the lower airways), biologics are now used in daily practice in many parts of the world. This pocket guide is aimed at all specialists treating adult patients with severe airway disease.
Source: Rhinology Journal
DOI: 10.4193/rhin24.510
Authors: W J Fokkens, V Backer, V J Lund, P J Barnes, M Bernal-Sprekelsen, L Bjermer, E de Corso, D M Conti, M E Cornet, Z Diamant, R Djukanovic, M Gaga, P Gevaert, J K Han, C Hopkins, G Joos, B N Landis, S Lau, S E Lee, J Mullol, A T Peters, G K Scadding, S Schneider, B Senior, I D Pavord, S Quirce, D Ryan, M E Wechsler, P W Hellings
Institutions: Amsterdam University Medical Centers, University of Amsterdam, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, Royal National Throat Nose and Ear Hospital, University College London, Imperial College London, Hospital Clínic de Barcelona, Universitat de Barcelona, Lund University, Skåne University Hospital, Agostino Gemelli University Polyclinic, Istituti di Ricovero e Cura a Carattere Scientifico, Alrijne Ziekenhuis, University Medical Center Groningen, NIHR Southampton Biomedical Research Centre, University of Southampton, Hygeia Hospital, Ghent University, Eastern Virginia Medical School, King's College London, University Hospital of Geneva, Charité - Universitätsmedizin Berlin, Brigham and Women's Hospital, Harvard University, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Northwestern University, Medical University of Vienna, University of North Carolina at Chapel Hill, University of Oxford, Hospital Universitario La Paz, University of Edinburgh, National Jewish Health, Universitair Ziekenhuis Leuven, KU Leuven
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4408245204