Work

Enhancer binding as a KEysTONE of fasting response

Year: 2025

Type: article

Abstract: Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer priming as a keystone for ketone production, increasing our understanding of mechanisms underlying metabolic benefits of alternate-day fasting (ADF).

Source: Trends in Endocrinology and Metabolism

DOI: 10.1016/j.tem.2025.02.002

Authors: Nathaniel F. Henneman, Ganna Panasyuk

Institutions: Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Institut Necker Enfants Malades

Language: English

Topic: Dietary Effects on Health

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030