Work

Prevalence of bacterial infections and factors associated with death related to these infections in two medical departments of a tertiary hospital in Dakar, Senegal

Year: 2025

Type: article

Abstract: • Prevalence of bacterial infection is high in internal medicine and infectious diseases departments of Dakar Principal Hospital. • The top 3 of bacterial species isolated was Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae. • More than the half of isolated bacteria were multidrug-resistant • Bacterial infections represent a major cause of death in medical departments of Dakar Principal Hospital • Patients with advanced age, prior hospitalization in the 6 previous months, low rate of hemoglobin were more at risk to die the aim of this study was to estimate the prevalence of bacterial infections and identify the factors associated with death related to these infections in the internal medicine (Brévié) and infectious diseases (Boufflers) departments of Dakar Principal Hospital. This was a cross-sectional study carried out from January 1, to December 31, 2023 including patients with bacterial infections hospitalized in Boufflers and Brévié. Multivariate logistic regression was used to identify factors associated with death. Out of 1,085 hospitalized patients, 181 (16.7%) had bacterial infections. The mean age was 60 ± 18 years, with a sex-ratio of 1.08. Urinary tract infection (37%) was the most represented clinical presentation. Bacteria were isolated in 123 patients (68%) with Escherichia coli (39%), Staphylococcus aureus (12%), and Klebsiella pneumoniae (12%) as the most represented species. Of the 140 identified bacteria, 78 (55.7%) were multidrug-resistant. The death rate was 15%. Multivariate analysis showed that age ≥ 65 years (OR = 3.2; 95%CI [1.2–9.5]), prior hospitalization (OR = 2.9; 95%CI [1.1–8.5]), and hemoglobin levels between 3.4 g/dL and 7 g/dL (OR = 11.7; 95%CI [2.5–60]) or between 8 g/dL and 11 g/dL (OR = 4.9; 95%CI [1.6–18.4]) compared to levels ≥ 11 g/dL were associated with death. This study showed a high prevalence and mortality rate of bacterial infections in internal medicine and infectious diseases departments, particularly among elderly patients, those with a history of hospitalization, or low hemoglobin levels.

Source: IJID Regions

DOI: 10.1016/j.ijregi.2025.100623