Work

Protometabolic functions of pyridoxal: A link between early amino acid synthesis and enzyme evolution

Year: 2025

Type: article

Abstract: In the framework of studies on protometabolism, Schlikker et al. characterized the conversion of pyridoxal to pyridoxamine under conditions mimicking the ones likely existing at the origin of metabolism. These conditions triggered nitrogen incorporation into amino acids in solution before the origins of enzymes. The suggested role for pyridoxal highlights its pivotal function in the transition from inorganic ammonia-dependent amino acid synthesis to organic reactions in aqueous solution and supports the "metabolism first" theory for biological evolution. Insights from the early evolution of natural enzymes can inspire the development of novel biocatalysts for biotechnological applications based on the catalytic versatility of pyridoxal.

Source: FEBS Journal

DOI: 10.1111/febs.70056

Authors: Mariarita Bertoldi, Gianluca Molla

Institutions: University of Verona, University of Insubria

Language: English

Topic: Origins and Evolution of Life

Subfield: Astronomy and Astrophysics

Field: Physics and Astronomy

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,000

Funders: Università degli Studi dell'Insubria, Università degli Studi di Verona