Work

Mimicking the CuD Site of pMMO via a Copper Cage‐Complex

Year: 2025

Type: article

Abstract: The mechanism of action of particulate monooxygenase (pMMO) has yet to be determined. The CuD site with two histidines and an asparagine coordinating to copper has been identified as a potential active site of pMMO. Here, we present a copper cage complex, that assembles this coordination sphere, being a structural mimic of the pMMO. The cage is capable to catalyze aerobic oxidations of organic substrates such as benzylic alcohols to aldehydes and hydroquinones to quinones. This is inspired by the reactivity that is observed for enzymatic active sites possessing copper.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202500533

Authors: Shunyi Miao, Leon Gerndt, Michael Roemelt, Matthias Otte

Institutions: University of Göttingen, Humboldt-Universität zu Berlin

Language: English

Topic: Metal-Catalyzed Oxygenation Mechanisms

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funder: Deutsche Forschungsgemeinschaft