Work

Caracterização de células-tronco em diferentes tecidos de animais e seu potencial terapêutico em medicina veterinária regenerativa

Year: 2025

Type: article

Abstract: Currently, stem cells have been the target of cellular therapies due to their plasticity and power to regenerate injured tissues. In this literature review, we address the currently most important stem cells, focusing on treatments using them. This study explores recent advances in the field, addressing the main sources of stem cells such as induced pluripotent, hematopoietic, adult and embryonic. The mechanisms of action of stem cells are analyzed with emphasis on their ability to differentiate into multiple cell lineages, secrete bioactive factors and stimulate tissue regeneration. Studies have also demonstrated the role of these cells in the tissue microenvironment, promoting angiogenesis, modulating inflammatory responses and favoring the repair of injured tissues. Promising results have been reported, such as functional improvement in cases of osteoarthritis, deep ulcerative corneal lesions, cutaneous lymphoma and chronic wounds. Despite this, challenges remain, including fully understanding cellular mechanisms, developing standardized protocols, and assessing long-term risks. This study provides a comprehensive overview of the current state of stem cell use in veterinary medicine, highlighting their potential impact on improving animal health and welfare. By consolidating existing knowledge and identifying gaps in research, we hope to boost the advancement of this field, promoting innovative and safe therapeutic solutions for animals.

Source: PubVet

DOI: 10.31533/pubvet.v19n03e1742

Authors: Giovanna Lagonegro Amanatidis, Patricia Franciscone Mendes

Institution: Centro Universitário das Américas (FAM) - São Paulo

Language: English

Topic: Mesenchymal stem cell research

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $76