Work

Six-step synthesis and epithelial-mesenchymal transition–inhibitory activity of a tetralone-based vitetrifolin analog

Year: 2025

Type: article

Abstract: We synthesized a vitetrifolin analog in which the A-ring was replaced with a benzene ring, in 6 steps from commercially available 2-methyl-1-tetralone. Similarly to vitetrifolin D, this analog suppressed the phorbol ester-induced epithelial-mesenchymal transition. This tetralone-based structural simplification strategy is expected to be applicable to studies on not only vitetrifolins but also other halimane-type diterpenoids.

Source: Bioscience Biotechnology and Biochemistry

DOI: 10.1093/bbb/zbaf030

Authors: Yusuke Hanaki, Yasunori Sugiyama, Ryo C Yanagita

Institution: Kagawa University

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,272

Funder: Japan Society for the Promotion of Science