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Evaluation of Potential Drug–Drug Interactions with Antimicrobials among Critically Ill Patients in Intensive Care Units of a Tertiary Care Hospital: A Cross-Sectional Study

Year: 2025

Type: article

Abstract: A BSTRACT Background: Critically ill patients in intensive care units (ICUs) are often prescribed multiple drugs, including antimicrobials, increasing the risk of drug–drug interactions (DDIs). This study evaluated the frequency, mechanisms, and severity of potential DDIs with antimicrobials in such patients. Methods: A cross-sectional study was conducted among 292 critically ill patients in the ICU of M S Ramaiah Hospitals from December 2018 to June 2020. Patient data, including demographics and prescribed drugs, were collected. DDIs were analyzed using Micromedex Drug Interaction Checker and classified by mechanism and severity. Results: Of the 292 patients, 35.3% experienced DDIs involving antimicrobials. A total of 220 DDIs were identified, primarily pharmacodynamic (82.73%) and major in severity (68.63%). The occurrence of DDIs correlated significantly with the number of drugs prescribed (r = 0.26, P = 0.005). Conclusion: The findings highlight the need for careful drug monitoring and dose adjustments to minimize antimicrobial-related DDIs in critically ill patients.

Source: Journal of Pharmacy And Bioallied Sciences

DOI: 10.4103/jpbs.jpbs_1870_24

Authors: T. Abhishek, N. Mukunda, K. Rooparani

Institutions: Johnson & Johnson (India), M.S. Ramaiah Medical College

Language: English

Topic: Pharmaceutical Practices and Patient Outcomes

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250