Unexpected Primaquine‐Induced Hemolysis in a G6PD ‐Normal Patient: A Case Report From Nepal
Year: 2025
Type: article
Study design: Case Report
Abstract: ABSTRACT Primaquine, an antimalarial drug, is essential for preventing relapses of Plasmodium vivax . However, it poses a risk of hemolytic anemia, particularly in glucose‐6‐phosphate dehydrogenase (G6PD) deficient patients. This case report details a 27‐year‐old male with normal G6PD levels who developed hemolytic anemia following primaquine therapy for P. vivax malaria. Despite a normal quantitative G6PD analysis, the patient experienced a significant drop in hemoglobin, necessitating early discontinuation of the drug. This case highlights the potential for hemolysis in G6PD‐normal patients, underscoring the importance of close monitoring and the limitations of current G6PD screening methods.
Source: Clinical Case Reports
DOI: 10.1002/ccr3.70303
Authors: Aarju Khadka, Sachet Subedi, Nisha Lama, Indu Bhattarai, Chandrashekhar Deuba, Uttam Khatri, Nisha Regmi
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,820
OpenAlex ID: W4408301032