Immune checkpoint inhibitors and IgA nephropathy; A rare side effect
Year: 2025
Type: article
Abstract: The pathophysiological mechanisms of secondary IgA nephropathy (IgAN) containing IgA-mediated immune complex deposition in the glomeruli. However, the specific triggers can vary widely, including infections, liver disease, and malignancies, in addition to drug-induced factors. IgAN is a rare however is a serious complication of immune checkpoint inhibitor (ICI) therapy that can lead to acute kidney injury. Clinically, the diagnosis of sIgAN typically follows a temporal association between medication administration and the onset of renal symptoms, such as hematuria or proteinuria. A kidney biopsy is often necessary to confirm the diagnosis and rule out other causes of nephropathy
Source: Journal of Nephropharmacology
Institution: Isfahan University of Medical Sciences
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408302264