Work

Article of Significant Interest in This Issue

Year: 2025

Type: article

Abstract: Group A Streptococcus virulence is promoted by superantigen toxins that strongly activate T cells. Johnson et al. (e00405-24) show a critical dual role for a bacterial protease in the post-translational regulation of superantigens. Acting as a rheostat, it can degrade them to limit excessive activity and also amplify their activity through independent, complementary targeting of host cell signaling. These results show additional selection in the evolution of these toxins and new targets in the control of rheumatic fever and toxic shock syndrome.

Source: Infection and Immunity

DOI: 10.1128/iai.00105-25

Language: English

Topic: Streptococcal Infections and Treatments

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408302624

FWCI:

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Related to: 10