Work

Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori

Year: 2025

Type: article

Abstract: OBJECTIVE: Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection. RESULTS: Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included. One hundred and eighty (60%) patients were negative and 120 (40%) positive for H. pylori. Associations between the presence of H. pylori and age, gender, or other demographics were statistically insignificant (p > 0.05). The prevalence of F. nucleatum infection was determined for the two patient categories: 215 patients (72%) were positive for F. nucleatum; of these cases, 95 showed evidence of, and 120 lacked, concomitant H. pylori infection. Gastric biopsies obtained from patients with gastric cancer but negative for H. pylori revealed a significant prevalence of F. nucleatum infection.

Source: BMC Research Notes

DOI: 10.1186/s13104-025-07165-8

Authors: Negin Kamali, Amin Talebi Bezmin Abadi, Farid Rahimi, Mojgan Forootan

Institutions: Tarbiat Modares University, Australian National University, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Helicobacter pylori-related gastroenterology studies

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,690