Inter-rater reliability of muscle ultrasonography performed by multidisciplinary novice sonographers in the evaluation of critically ill patients with acute kidney injury requiring continuous kidney replacement therapy
Year: 2025
Type: article
Abstract: Early diagnosis of muscle wasting in critically ill patients with acute kidney injury requiring continuous kidney replacement therapy (AKI-CKRT) may improve outcomes via timely rehabilitation and nutrition. Muscle ultrasound (MUS) has recently gained traction for assessing muscle atrophy in the intensive care unit (ICU) but requires training to achieve reproducibility. We evaluated the inter-rater reliability of MUS in patients with AKI-CKRT performed by multidisciplinary raters including nephrologists. Two blinded independent raters used portable ultrasound to acquire images of the rectus femoris (RF). All raters were clinicians routinely caring for patients with CKRT in the ICU and were initially novices in MUS. They underwent three two-hour teleconference training sessions in MUS led by an experienced physiotherapist. Inter-rater reliability was evaluated with intraclass correlation coefficients (ICCs) [95% confidence interval] using a two-way random-effects model. We analyzed 54 MUS images (27 pairs) from nine patients at baseline (n = 16), day 3 (n = 6), day 7 (n = 8), ICU discharge (n = 10), hospital discharge (n = 10), and 1–3 months after discharge (n = 4). The mean (±standard deviation) values of RF thickness, cross-sectional area, and echointensity were 1.7 ± 1.4 cm, 4.6 ± 2.7 cm2, and 84.0 ± 17.7 AU, respectively. Reliability was excellent for RF thickness (ICC = 0.96 [0.91–0.98], p < 0.001) and cross-sectional area (ICC = 0.92 [0.83–0.96], p < 0.001) but poor for echointensity (ICC = 0.41 [0.04–0.68], p < 0.05). These results demonstrate reliable assessment of muscle size in patients with AKI-CKRT using ultrasound performed by multidisciplinary novice sonographers trained via teleconference, suggesting that this methodology may be useful in future studies of muscle wasting in patients with AKI-CKRT.
Source: Renal Failure
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,306
Funders: Eli Lilly and Company, Pfizer, Novo Nordisk, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities
Awards: G1056151686, G4231987921, UAB-UCSD O'Brien Center for Acute Kidney Injury Research, G7718117650, G77486010, The Southeastern Acute Kidney Injury (SEAK) Alliance for the COPE-AKI Consortium, The Relation of Soluble Klotho with Cardiovascular Disease, Chronic Kidney Disease Progression, and Blood Pressure in the Systolic Blood Pressure Intervention Trial, Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness
OpenAlex ID: W4408310866