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Crystal structure of flumethasone, C 22 H 28 F 2 O 5

Year: 2025

Type: article

Abstract: The crystal structure of flumethasone has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory techniques. Flumethasone crystallizes in space group P2 1 (#4) with a = 6.46741(5), b = 24.91607(20), c = 12.23875(11) Å, β = 90.9512(6)°, V = 1971.91(4) Å 3 , and Z = 4 at 298 K. The crystal structure consists of O–H⋯O hydrogen-bonded double layers of flumethasone molecules parallel to the ac -plane. The powder pattern has been submitted to ICDD for inclusion in the Powder Diffraction File™ (PDF®).

Source: Powder Diffraction

DOI: 10.1017/s0885715625000120

Authors: James A. Kaduk, Anja Dosen, Thomas N. Blanton

Institutions: Illinois Institute of Technology, North Central College, International Centre for Diffraction Data

Language: English

Topic: X-ray Diffraction in Crystallography

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,550

OpenAlex ID: W4408312132

FWCI:

Cites: 25

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Related to: 10