Work

Environment of Solvent-Controlled Chemoselective Asymmetric Hydroperoxidation and Hydroxylation of 5-Pyrazolone Ketimines Catalyzed by Bifunctional Organocatalysts

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Chemoselectivity often garners significant attention in organic synthesis, serving as a primary strategy for producing a variety of functionalized products from the same substrate. The first environment of solvent-controlled chemoselective asymmetric hydroperoxidation and hydroxylation of 5-pyrazolone ketimines has been achieved, using an acid–base bifunctional chiral squaramide as the organocatalyst, affording a range of enantioenriched products of hydroperoxidation and hydroxylation with high stereoselectivities (up to 90% ee ).

Source: ACS Omega

DOI: 10.1021/acsomega.4c10608

Authors: Xiangfeng Lin, Bo Long, Hanhui Lei, Terence Xiaoteng Liu, Zhanhui Yuan

Institutions: Fujian Agriculture and Forestry University, Northumbria University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,935

Funders: Natural Science Foundation of Fujian Province, Fujian Provincial Department of Science and Technology