Intracellular Crystals in Chronic Lymphocytic Leukemia
Year: 2025
Type: article
Study design: Case Report
Abstract: An 81-year-old man presented with weight loss and lymphocytosis with a white blood cell count of 55,000/µL with 80% lymphocytosis and 20% segmented neutrophils. Hemoglobin was 14 g/dL and platelets 139 × 103/µL. In flowcytometric analysis of peripheral blood, the CD19-expressing lymphocytes (52%) were positive for CD5, CD23, and CD200 and they were negative for CD10, CD103, CD25, and T-cell markers. There was no surface expression of light chains. Serum protein electrophoresis revealed mild hypogammaglobulinemia (0.60 g/dL, normal >0.69) and on immunofixation electrophoresis there was a small monoclonal spike of IgG Lambda.
Authors: Sarvari Yellapragada, Perumal Thiagarajan
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4408316989