Work

VOLTAGE-OPERATED AND NON-VOLTAGE-OPERATED Ca2+ ENTRY PATHWAYS IN GASTROENTEROPANCREATIC NEUROENDOCRINE TUMOR CELL LINES

Year: 2020

Type: book-chapter

Abstract: The role for Ca2+ in cancer-related cell signaling pathways is well established. Alterations in Ca2+ homeostasis increase proliferation and induce dierentiation and apoptosis. According to a growing number of studies, Ca2+ channels voltage- and nonvoltage-gated family represents key players in calcium homeostasis and cell physiopathology. We proposed that Ca2+ entry through plasma membrane channels could provide an additional or alternative pathway for modulation of cell growth in gut neuroendocrine cells. To investigate this possibility, we characterized Ca2+ entry in a set of human carcinoid cell lines originating in the foregut, midgut and hindgut as a starting point for an inquiry into the role of Ca2+ signaling pathways in carcinoid cancer. To test this hypothesis, we used RT-PCR to profile a variety of voltage-operated and non-voltage-operated Ca2+ permeable channels and then characterized VOCE and SOCE in the carcinoid cell lines.

Source: PH "Akademperiodyka" eBooks

DOI: 10.15407/biph.books.essneur.285

Authors: T. ZHELAI, S. ARUNACHALAM, D.R. GIOVANNUCCI

Institutions: Bogomoletz Institute of Physiology, Taras Shevchenko National University of Kyiv, University of Toledo

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Toledo, Raymond and Beverly Sackler Foundation