Evaluation of coordination chemistry and structure‐antioxidant efficacy of some di and tributyl tin(IV) complexes derived from nitrogen, oxygen‐containing organic ligands
Year: 2025
Type: article
Abstract: Thermodynamic characteristics, molecular electrostatic potential, optimal structures, and quantum chemical descriptors of various di‐and tributyltin(IV) complexes were provided by the computational modeling. DFT assesses these organic‐inorganic hybrid tin(IV) complexes’ coordination chemistry and structural diversity. The current work uses computational modeling to visualize tin(IV) complexes at the molecular level. The organic modifiers that make up the complex's constituent parts determine the antioxidant capacity of the compound. The antioxidant potential of dibutyltin(IV) complexes of flexible N‐protected amino acids and ketoxime possess general formula Bu2SnAO, where [where R = ─CH3; ─CHR─ = ─CH2CH2─; R = −CH2C6H5; R = −CH(CH3)2] and OH = R1 R2C = NOH or [where R1 = R2 = ─CH3; R1 = ─CH3, R2 = ─C6H5; R3 = ─C5H10‐; R3 = ─(C6H4)NHC(O)─] were investigated by DPPH method. Another series of tributyltin(IV) complexes with Schiff bases of heterocyclic β‐diketones having general formula Bu3SnL [where LH = with R = ─CH3, ─C6H5, ─C6H4Cl(p) and Ζ = ─C6H5, ─C6H4Cl(m), ─C6H4Cl(p)] were exhibit antioxidant potential. Analysis was done to evaluate the different structural scaffolds of di‐and tributyltin(IV) complexes, which provide the antioxidant potential to these complexes. The objective of the current work is to correlate the structural‐activity relationship of the di‐and tributyltin(IV) complexes. Utilizing the DPPH radical, these complexes exhibit free radical scavenging action. The IC‐50 values indicate that as compared to tributyltin(IV) complexes, mixed ligand dibutyltin(IV) complexes have greater antioxidant potential.
Source: Vietnam Journal of Chemistry
DOI: 10.1002/vjch.70000
Authors: Shobhana Sharma, Shobhana Sharma, Sushil Kumar Sharma, Sushil Kumar Sharma, Ankit Sharma
Institution: University of Kota
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,400
OpenAlex ID: W4408320200