Author response: Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike
Year: 2025
Type: peer-review
Abstract: AssessmentThis manuscript focuses on understanding if and how the glycosylation of SARS-CoV2 spike protein affects a putative allosteric network of interactions controlled by the binding of a fatty acid.The main conclusion is that glycans do not significantly affect the network of allosteric interactions.This valuable information -albeit mainly consisting of negative results -is based on convincing evidence.It will be of interest to scientists focusing on SARS CoV2 protein structure and dynamics.
Source: eLife
Institutions: University of Bristol, University of California San Diego
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
Funders: National Science Foundation, Research Corporation for Science Advancement, Wellcome Trust, American Society of Forensic Odontology, UK Research and Innovation, University of Bristol, Directorate for Biological Sciences, University of California, San Diego, Medical Research Council, Engineering and Physical Sciences Research Council, Biotechnology and Biological Sciences Research Council, H2020 European Research Council
Awards: Expanding the capabilities and use of the South West Regional Facility for High-Resolution Electron Cryo-microscopy, G2109111079, Novel platforms to develop polyspecifically-effective, safe, affordable and thermostable monoclonal camelid VHH nanobodies to treat snake venom-induced necrosis in India and sub-Saharan Africa, G339059223, G4114594511, Predictive computational models for Enzyme Dynamics, Antimicrobial resistance, Catalysis and Thermoadaptation for Evolution and Design, The G2P2 virology consortium: keeping pace with SARS-CoV-2 variants, providing evidence to vaccine policy, and building agility for the next pandemic, Creating and comprehending the circuitry of life: precise biomolecular design of multi-centre redox enzymes for a synthetic metabolism, G6085025897, Dynamical-nonequilibrium simulations: an emerging approach to study time-dependent structural changes in proteins, South West Regional Facility for High-Resolution Electron Cryo-Microscopy, G8415457339, RAPID: Understanding the Effects of Glycosylation on Spike Vulnerabilities and the Host Range of SARS-CoV-2
OpenAlex ID: W4408328074