Work

Exploring metallic nanoparticles for enhanced multiplexed SERS for diagnostics.

Year: 2025

Type: conference-paper

Abstract: When it comes to diagnostics and disease management, while physicians focus on the prognosis and mortality caused by viral diseases, it is necessary to be thorough about metabolic chronic illnesses that could cause complications. Owing to its remarkable sensitivity and capability for multiplexing, Surface-Enhanced Raman Spectroscopy (SERS) emerges as a potent analytical approach with substantial promise in the realms of bioanalysis and diagnostics. This work focuses on exploring metallic nanoparticles that can be used for SERS-based pathogen and metabolic disorder-biomarkers detection for rapid viral infection and chronic disease diagnosis using SARS-CoV-2 or HIV pseudo-virus and a diabetes biomarker, glucose. Herein, metallic nanoparticles (NPs) such as gold (Au) and silver (Ag) nanoparticles, were assessed for their sensitivity in detecting both disease-biomarkers in a buffer containing HIV pseudo-virus and glucose.

Source: Journal of Physics Conference Series

DOI: 10.1088/1742-6596/2970/1/012011

Authors: Lungile Nomcebo Thwala, Lebogang Thobakgale, Zenande Mcotshana, Moratoa Tlomatsane, Saturnin Ombinda-Lemboumba, Masixole Lugongolo, Patience Mthunzi-Kufa

Institutions: Council for Scientific and Industrial Research, University of Cape Town, University of South Africa

Language: English

Topic: Gold and Silver Nanoparticles Synthesis and Applications

Subfield: Electronic, Optical and Magnetic Materials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408329095

FWCI: 5.113

Cites: 9

Cited by: 1

Related to: 10