Year: 2025
Type: article
Study design: Observational Study
Abstract: It is known that uromodulin excretion (Umod) is associated with fractional excretions of uric acid (UrAc), chloride and sodium (markers of volume overload). However, the relationship between Umod and blood UrAc (sUrAc) is not yet fully determined. The objective: to analyze the relationship between sUrAc and Umod levels and assessment of the influence of sUrAc on Umod in the Umod-sUrAc model. Materials and methods. In 2021–2023 the ROLUNT (uROmoduLin, UbiquinoNe, glutaThione) study was conducted at LLC “VETA-PLUS” and the CDC of the Brovary Multidisciplinary Clinical Hospital, which are the clinical bases of the Department of Nephrology and Renal Replacement Therapy of the Shupyk National University of Healthcare of Ukraine. The study included 89 patients aged 18 to 64 years with a sUrAc level less than 360 μmol/l, namely: 63 patients had chronic kidney disease (CKD) stages 1–3, 26 patients without signs of CKD and/or acute kidney injury. Results. The analysis of patient examinations and Spearman correlation results demonstrated a significant positive relationship between fractional excretion of Umod (FeUmod) and the index of urine albumin (uAlb)/urine creatinine (uCrea), urinary Umod (uUmod)/uCrea, blood urea (sUrea), urea nitrogen (BUN), blood creatinine (sCrea), risk index of development of terminal stage of CKD after 2 years (QxMD2) and after 5 years (QxMD5); between uAlb/uUmod and age, uAlb, uAlb/uCrea, QxMD2, QxMD5; between uUmod and daily uUmod (uUmod24), uUmod/serum Umod (sUmod); between uUmod24 and uUmod/sUmod, uUmod/eGFR according to the CKD-EPI formula (eGFRckd); between uUmod/uCrea and uUmod/rGFRckd, uAlb/uCrea; between uUmod/rGFRckd and uUmod24, QxMD2, QxMD5, uUmod/uCrea. Conclusions. The results of the study indicate the complex relationships between Umod and UrAc, which may affect the health status of patients with CKD. The lack of correlation between Umod and UrAc indicates independent mechanisms of regulation of these indicators.
Authors: Lidiia Denova, Stella Kushnirenko
Institution: Shupyk National Healthcare University of Ukraine
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408330647