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131-Radioiodine Therapy for Graves Disease in a Patient With Down Syndrome and Non-operable Congenital Heart Disease

Year: 2025

Type: article

Abstract: Thyroid dysfunctions are prevalent in Down syndrome (DS), with hypothyroidism being the most frequent occurrence, whereas hyperthyroidism is rare. DS patients face an increased risk of comorbidities, including gastrointestinal, cardiac, and pulmonary anomalies, as well as developmental delays, endocrine abnormalities, and malignancies, complicating their treatment and management. The published data on pediatric hyperthyroidism in DS from India comprise five case reports with six patients. We report a case of a 13-year-old male child with DS with Graves disease (GD), who had inoperable congenital heart disease (CHD) and was administered iodine-131 radioiodine therapy as a definitive treatment for GD.

Source: Cureus

DOI: 10.7759/cureus.80396

Authors: Ketki Ambulkar, Vyankatesh Shivane, Rohit Barnabas, Vikram Lele, Tushar Bandgar

Institutions: King Edward Memorial Hospital and Seth G.S. Medical College, Jaslok Hospital

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408336554

FWCI: 0.591

Cites: 12

Cited by: 1

Related to: 10