Work

Inflammatory bowel disease and hereditary hemochromatosis: A case series

Year: 2025

Type: article

Abstract: We report a case series of three pediatric patients with inflammatory bowel disease (IBD) and variants in HFE which causes hereditary hemochromatosis (HH) type 1. Mice models suggest that these patients may be at increased risk for colitis and colon cancer. We detail the clinical course of these patients regarding IBD and iron overload and HFE‐related comorbidities. We also review the known literature regarding HH and IBD overlap, HH detection and screening recommendations, HH management strategies, and iron management strategies in the context of both iron overload risk and IBD.

Source: JPGN Reports

DOI: 10.1002/jpr3.12167

Authors: Jackson Fein, Amber Hildreth, Lillian J. Choi, Jeannie S. Huang

Institutions: University of California San Diego, Rady Children's Hospital-San Diego

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $1,900