Hyponatremia in Acute Myocardial Infarction and Short-term Clinical Outcome: a Cross-sectional Study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objectives: Neurohumoral activation in acute myocardial infarction (MI) causes hyponatremia and is associated with poor outcome. We aimed to establish a relationship between hyponatremia in acute ST-elevation MI (STEMI) and its complications. Methods: Patients with acute STEMI were included. The patients were monitored for serum sodium at admission; at 24, 48, and 72 h; and echocardiographic evaluation at admission and at 72 h. Complications such as left ventricular (LV) failure and mortality during hospital stay were noted. Results: In the acute setting of STEMI, hyponatremia was observed in 86% of patients aged >60 years (p=0.001). In patients with moderate LV dysfunction, 91% had hyponatremia at 24 h after admission, with persistent hyponatremia in 66.7% at 72 h (p=0.02). Within 24 h of admission, when the patient had normal serum sodium, the risk of complications was 16%, with mild hyponatremia the risk was 66.7%, with moderate hyponatremia the risk was 85.7%, and with severe hyponatremia the risk was 100% (p=0.001). Conclusion: Elderly individuals are prone to hyponatremia following acute MI. LV dysfunction is associated with hyponatremia following MI. Moderate-to-severe hyponatremia is associated with a high risk of complications.
Authors: NAVEEN KUMAR G, ANANDI C, SEENIVASAN M
Institution: Madras Medical College
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408338864