Transformative Results in Giant Pyoderma Gangrenosum with Dexamethasone-cyclophosphamide Pulse
Year: 2025
Type: article
Abstract: Pyoderma gangrenosum (PG) is a cutaneous ulcerative condition that can present in various forms, including ulcerative, bullous, pustular, vegetative, and peristomal. It often occurs and recurs in areas subjected to trauma due to the pathergy phenomenon, where irritation or injury triggers flare-ups. The condition typically begins as a painful erythematous lesion that rapidly progresses to a necrotic or blistering ulcer. PG is commonly associated with systemic conditions such as rheumatologic diseases, paraproteinemia, inflammatory bowel disease, and hematologic cancers. Active or poorly controlled PG can result in significant morbidity, including severe pain, loss of mobility, and anemia of chronic disease. Diagnosis is primarily clinical, and treatment is generally focused on systemic corticosteroids. Complete healing may take months, with ongoing maintenance therapy. However, long-term immunosuppression can lead to various adverse effects. Despite recent therapeutic advances, the prognosis of pyoderma gangrenosum remains unpredictable.
Source: Annals of African Medicine
Authors: Avinash Jadhav, Jahanvi Goyal, Amit Girme, Kirti Shrikant Deo
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4408342533