Work

Evaluation of omadacycline in vitro activity against Corynebacterium species

Year: 2025

Type: article

Abstract: ABSTRACT Corynebacterium spp. are gram-positive bacteria increasingly recognized as pathogens. This study evaluates the MICs of omadacycline, a tetracycline, against 40 clinical Corynebacterium isolates using two methodologies: broth microdilution (BMD) and Liofilchem omadacycline MIC Test Strip (MTS). By BMD, the MIC 50 , MIC 90 , and MIC range were 0.5 µg/mL, 1 µg/mL, and 0.12–2.0 µg/mL, respectively. Comparing BMD to MTS, essential agreement (EA, within ±1 doubling dilution of the reference BMD MIC) was 87.5% (95% CI: 73.0%–95.4%).

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01864-24

Authors: Saltanat Ualiyeva, Justin McCallum, Alexander Donald Pyden, Zoe Freeman Weiss

Institutions: Tufts Medical Center, Lahey Hospital and Medical Center, Lahey Medical Center

Language: English

Topic: Diphtheria, Corynebacterium, and Tetanus

Subfield: Endocrinology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408343972

FWCI: 0.549

Cites: 26

Cited by: 1

Related to: 10