Serum intestinal permeability biomarkers are associated with erosive hand osteoarthritis and radiographic severity: results from the DIGICOD cohort
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA). METHODS: Serum concentrations of four intestinal permeability biomarkers (lipopolysaccharide binding protein (LBP), FABP2, sCD14, Zonulin-related proteins (ZRP) along with calprotectin, and high-sensitivity C-Reactive Protein (hs-CRP) were assessed in 410 patients of the DIGICOD cohort. The study compared patients with EHOA (≥ 2 erosion in Verbruggen score N=140) to those without EHOA (N=270) using the Mann-Whitney U test. Logistic regression was performed to adjust for potential covariates. The Spearman rank test was used to investigate the correlation between intestinal permeability biomarkers and seven clinical variables associated with HOA clinical and radiographic severity. RESULTS: Serum levels of LBP and ZRP were found to be higher in patients with EHOA compared to those without EHOA (p=0.001, p=0.04). Additionally, LBP and ZRP remained associated with EHOA in a logistic regression model adjusted for age, body mass index, and sex (p=0.017, p=0.005). ZRP was positively correlated with Verbruggen score and Kellgren-Lawrence sum score of both hands (r=0.14 p=0.005, r=0.12 p=0.023). LBP was positively correlated with the number of erosive joints (r=0.14 p=0.0006). Hs-CRP and LBP were positively correlated with AUSCAN pain (r=0.14 p=0.008, r=0.10 p=0.042). CONCLUSIONS: LBP and ZRP were associated with EHOA with clinical and radiographic severity in HOA. These results overall support the role of intestinal permeability in both symptoms and structural alteration in HOA.
Source: Osteoarthritis and Cartilage
Authors: Marie Binvignat, Soraya Fellahi, Jean-Philippe Bastard, Alexandra Rousseau, Sophie Tuffet, Alice Courties, Audrey Pigenet, Kristell Wanherdrick, Margreet Kloppenburg, Pascal Richette, Emmanuel Maheu, Michel D. Crema, David Klatzmann, Harry Sokol, Encarnita Mariotti-Ferrandiz, Francis Berenbaum, Jérémie Sellam
Institutions: Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Hôpital Saint-Antoine, Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine, Centre de Recherche Saint-Antoine, Immunologie - Immunopathologie - Immunothérapie, Hôpitaux Universitaires Henri-Mondor, Université Paris-Est Créteil, Institut Mondor de Recherche Biomédicale, Leiden University Medical Center, Université Paris Cité, Bioscar, Hôpital Lariboisière, Institut National du Sport, de l'Expertise et de la Performance, AgroParisTech, Université Paris-Saclay, Microbiologie de l’alimentation au service de la santé, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Institut Universitaire de France
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,700
Funders: Pfizer, Société Française de Rhumatologie
OpenAlex ID: W4408348539