Work

Out of Breath, out of Options: Benralizumab as a Last Hope in ICU ‐Treated Near‐Fatal Eosinophilic Asthma: A Case Series

Year: 2025

Type: article

Abstract: Asthma exacerbations remain life-threatening events despite advancements in biologic therapies. This case series reports on four patients with near-fatal eosinophilic asthma exacerbations who had been admitted to intensive care and were treated with benralizumab as a last resort after failing maximal standard therapies. All patients exhibited marked blood or airway eosinophilia and required intensive care ventilatory support. Following the administration of benralizumab, significant clinical improvements were observed. This series highlights the potential role of benralizumab in treating life-threatening asthma exacerbations driven by eosinophilic airway inflammation and underlines the need for phenotyping and timely intervention in managing such patients with near-fatal asthma while also stressing the need for continued adherence to asthma guidelines to prevent these extreme situations.

Source: Respirology Case Reports

DOI: 10.1002/rcr2.70117

Authors: Lennart Conemans, Emel Demir, Martijn Bischoff, Frits Franssen, Sami Simons

Institutions: Maastricht University Medical Centre, Maastricht University, Ciro

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,130