Ligand-Accelerated, Copper-Catalyzed Aerobic Oxidative Dehydrogenation of Primary Amines to Nitriles
Year: 2025
Type: article
Abstract: A highly efficient copper-catalyzed oxidative dehydrogenation of primary amines to access nitriles has been developed. We found that DMAP was an efficient ligand for copper-catalyzed oxidation and molecular oxygen was a green oxidizing agent. This reaction exhibited excellent functional group compatibility and a broad substrate scope. Various benzylic, allylic, and aliphatic amines were selectively and effectively oxidized to the corresponding nitriles in high yields (up to 100%). The ligand DMAP not only accelerated the reaction rate but also enhanced the stability of the catalyst. The practicality of the reaction was illustrated on a gram scale, even at a lower catalyst loading and/or under bubble air conditions.
Source: ACS Omega
Institution: Fuzhou University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
OpenAlex ID: W4408351910