Work

Monoallelic expression in human immune cells: linking genotype to phenotype

Year: 2025

Type: article

Abstract: Patients with an inborn error of immunity (IEI) often show a complete penetrance of their disease-causing mutation, whereas other forms of IEI show a family pattern where many family members carrying the same mutation remain unaffected. The underlying mechanism, differential allele-specific expression, was recently and elegantly demonstrated by Stewart et al.

Source: Trends in Immunology

DOI: 10.1016/j.it.2025.02.005

Authors: Lennart Hammarström, Qiang Pan-Hammarström

Institution: Karolinska Institutet

Language: English

Topic: Immunodeficiency and Autoimmune Disorders

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030